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Observe Closely (one)crofelemer boosts levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Crofelemer has the potential to inhibit CYP3A4 at concentrations predicted during the intestine; not likely to inhibit systemically simply because minimally absorbed.Hyponatremia: Clinically important hyponatremia